4PP5

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 5-methyl UAB30 and the coactivator peptide GRIP-1

Summary for 4PP5

• Entry DOI: 10.2210/pdb4pp5/pdb
• Related: 3OAP 4K4J 4POH 4POJ 4PP3
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-(5-methyl-3,4-dihydronaphthalen-1(2H)-ylidene)octa-2,4,6-trienoic acid, ... (4 entities in total)
• Functional Keywords: ligand binding domain. 6-methyl uab30, rexinoid, cancer, lipid toxicity, ligand binding domain, 6-methyl uab30, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 27785.30

Authors

Xia, G.,Smith, C.D.,Muccio, D.D. (deposition date: 2014-02-26, release date: 2014-06-18, Last modification date: 2024-02-28)

• Primary citation: Atigadda, V.R.,Xia, G.,Desphande, A.,Boerma, L.J.,Lobo-Ruppert, S.,Grubbs, C.J.,Smith, C.D.,Brouillette, W.J.,Muccio, D.D.; Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.; J.Med.Chem., 57:5370-5380, 2014; PubMed: 24801499; DOI: 10.1021/jm5004792

Experimental method

X-RAY DIFFRACTION (2 Å)