4PO7

Structure of the Sortilin:neurotensin complex at excess neurotensin concentration

Summary for 4PO7

Entry DOI	10.2210/pdb4po7/pdb
Descriptor	Sortilin, Neurotensin/neuromedin N, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	10 bladed beta-propeller, protein sorting receptor, neurotensin, glycosylation, trans golgi network, protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	81715.12
Authors	Quistgaard, E.M.,Groftehauge, M.K.,Thirup, S.S. (deposition date: 2014-02-25, release date: 2014-07-23, Last modification date: 2020-10-21)
Primary citation	Quistgaard, E.M.,Grftehauge, M.K.,Madsen, P.,Pallesen, L.T.,Christensen, B.,Srensen, E.S.,Nissen, P.,Petersen, C.M.,Thirup, S.S. Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin. Protein Sci., 23:1291-1300, 2014 Cited by PubMed: 24985322 DOI: 10.1002/pro.2512 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation