4PO7

Structure of the Sortilin:neurotensin complex at excess neurotensin concentration

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sortilin	polymer	685	76774.7	1	UniProt (Q99523) Pfam (PF15902) Pfam (PF15901)	Homo sapiens (human)	100 kDa NT receptor, Glycoprotein 95, Gp95, Neurotensin receptor 3, NT3, NTR3
2	B, C (N, P)	Neurotensin/neuromedin N	polymer	13	1675.9	2	UniProt (P30990)	Homo sapiens	Large neuromedin N, NmN-125, Neuromedin N, NN, NmN, Neurotensin, NT, Tail peptide
3	D, E (B, C)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	F (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	G (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
6	H, I, J (A, N, P)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A: 45 - 723 (UniProt: Q99523)

PDB	External Database	Details
Met 617	Val 650	variant
His 724	-	expression tag
His 725	-	expression tag
His 726	-	expression tag
His 727	-	expression tag
His 728	-	expression tag
His 729	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	80126.6
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	2
	Total formula weight	415.4
All*	Total formula weight	81715.1

*Water molecules are not included.