4PKL

Bromodomain of Trypanosoma brucei BDF2 With IBET-151

4PKL の概要

• エントリーDOI: 10.2210/pdb4pkl/pdb
• 分子名称: Bromodomain factor 2, 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE, PHOSPHATE ION, ... (7 entities in total)
• 機能のキーワード: signaling protein, inhibitor, histone, epigenetic reader, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28131.84

構造登録者

Debler, E.W. (登録日: 2014-05-15, 公開日: 2015-11-18, 最終更新日: 2023-12-27)

• 主引用文献: Schulz, D.,Mugnier, M.R.,Paulsen, E.M.,Kim, H.S.,Chung, C.W.,Tough, D.F.,Rioja, I.,Prinjha, R.K.,Papavasiliou, F.N.,Debler, E.W.; Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.; Plos Biol., 13:e1002316-e1002316, 2015; PubMed: 26646171; DOI: 10.1371/journal.pbio.1002316

実験手法

X-RAY DIFFRACTION (1.251 Å)