4PID

Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor

Summary for 4PID

• Entry DOI: 10.2210/pdb4pid/pdb
• Related: 1NLN 4PIE
• Descriptor: Protease, Pre-protein VI, ACETATE ION, ... (5 entities in total)
• Functional Keywords: adenain, cysteine protease, adenovirus, pvic cofactor, virus maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human adenovirus 2 (HAdV-2); More
• Cellular location: Virion : P03252; Pre-protein VI: Host nucleus . Endosome lysis protein: Virion : P03274
• Total number of polymer chains: 2
• Total formula weight: 24767.29

Authors

Mac Sweeney, A.,Grosche, P.,Ellis, D.,Combrink, K.,Erbel, P.,Hughes, N.,Sirockin, F.,Melkko, S.,Bernardi, A.,Ramage, P.,Jarousse, N.,Altmann, E. (deposition date: 2014-05-08, release date: 2014-09-10, Last modification date: 2023-09-27)

• Primary citation: Mac Sweeney, A.,Grosche, P.,Ellis, D.,Combrink, K.,Erbel, P.,Hughes, N.,Sirockin, F.,Melkko, S.,Bernardi, A.,Ramage, P.,Jarousse, N.,Altmann, E.; Discovery and structure-based optimization of adenain inhibitors.; Acs Med.Chem.Lett., 5:937-941, 2014; PubMed: 25147618; DOI: 10.1021/ml500224t

Experimental method

X-RAY DIFFRACTION (1.59 Å)