4PID
Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor
Summary for 4PID
Entry DOI | 10.2210/pdb4pid/pdb |
Related | 1NLN 4PIE |
Descriptor | Protease, Pre-protein VI, ACETATE ION, ... (5 entities in total) |
Functional Keywords | adenain, cysteine protease, adenovirus, pvic cofactor, virus maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human adenovirus 2 (HAdV-2) More |
Cellular location | Virion : P03252 Pre-protein VI: Host nucleus . Endosome lysis protein: Virion : P03274 |
Total number of polymer chains | 2 |
Total formula weight | 24767.29 |
Authors | Mac Sweeney, A.,Grosche, P.,Ellis, D.,Combrink, K.,Erbel, P.,Hughes, N.,Sirockin, F.,Melkko, S.,Bernardi, A.,Ramage, P.,Jarousse, N.,Altmann, E. (deposition date: 2014-05-08, release date: 2014-09-10, Last modification date: 2023-09-27) |
Primary citation | Mac Sweeney, A.,Grosche, P.,Ellis, D.,Combrink, K.,Erbel, P.,Hughes, N.,Sirockin, F.,Melkko, S.,Bernardi, A.,Ramage, P.,Jarousse, N.,Altmann, E. Discovery and structure-based optimization of adenain inhibitors. Acs Med.Chem.Lett., 5:937-941, 2014 Cited by PubMed: 25147618DOI: 10.1021/ml500224t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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