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4PHM

The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids

Summary for 4PHM
Entry DOI10.2210/pdb4phm/pdb
Related4PHJ
DescriptorCalpain small subunit 1, 3-(5-bromo-1H-indol-3-yl)-2-thioxopropanoic acid, CALCIUM ION, ... (4 entities in total)
Functional Keywordscalpain, domain vi, pef(s), human, calcium binding, protease, ef-hand, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P04632
Total number of polymer chains2
Total formula weight40950.15
Authors
Rizkallah, P.J.,Allemann, R.K.,Adams, S.E.,Miller, D.J.,Hallett, M.B. (deposition date: 2014-05-06, release date: 2014-08-13, Last modification date: 2023-12-20)
Primary citationAdams, S.E.,Rizkallah, P.J.,Miller, D.J.,Robinson, E.J.,Hallett, M.B.,Allemann, R.K.
The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187:236-241, 2014
Cited by
PubMed: 25086406
DOI: 10.1016/j.jsb.2014.07.004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

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