4PHK
The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid
Summary for 4PHK
Entry DOI | 10.2210/pdb4phk/pdb |
Related | 4PHJ |
Descriptor | Calpain small subunit 1, (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | domain vi, pef(s), calcium binding, protease, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P04632 |
Total number of polymer chains | 2 |
Total formula weight | 40783.18 |
Authors | Rizkallah, P.J.,Allemann, R.K.,Adams, S.E.,Miller, D.J.,Hallett, M.B.,Robinson, E. (deposition date: 2014-05-06, release date: 2014-08-13, Last modification date: 2024-05-08) |
Primary citation | Adams, S.E.,Rizkallah, P.J.,Miller, D.J.,Robinson, E.J.,Hallett, M.B.,Allemann, R.K. The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids. J.Struct.Biol., 187:236-241, 2014 Cited by PubMed: 25086406DOI: 10.1016/j.jsb.2014.07.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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