4PHK

The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid

Summary for 4PHK

• Entry DOI: 10.2210/pdb4phk/pdb
• Related: 4PHJ
• Descriptor: Calpain small subunit 1, (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: domain vi, pef(s), calcium binding, protease, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P04632
• Total number of polymer chains: 2
• Total formula weight: 40783.18

Authors

Rizkallah, P.J.,Allemann, R.K.,Adams, S.E.,Miller, D.J.,Hallett, M.B.,Robinson, E. (deposition date: 2014-05-06, release date: 2014-08-13, Last modification date: 2017-09-13)

• Primary citation: Adams, S.E.,Rizkallah, P.J.,Miller, D.J.,Robinson, E.J.,Hallett, M.B.,Allemann, R.K.; The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.; J.Struct.Biol., 187:236-241, 2014; PubMed: 25086406; DOI: 10.1016/j.jsb.2014.07.004

Experimental method

X-RAY DIFFRACTION (2.05 Å)