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4PH4

The crystal structure of Human VPS34 in complex with PIK-III

Summary for 4PH4
Entry DOI10.2210/pdb4ph4/pdb
DescriptorPhosphatidylinositol 3-kinase catalytic subunit type 3, GLYCEROL, 4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diamine, ... (4 entities in total)
Functional Keywordsvps34, autophagy, class iii, phosphatidylinositol-3-kinase, pik3c3, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationMidbody: Q8NEB9
Total number of polymer chains1
Total formula weight72256.51
Authors
Knapp, M.S.,Elling, R.A. (deposition date: 2014-05-04, release date: 2014-10-29, Last modification date: 2023-12-27)
Primary citationDowdle, W.E.,Nyfeler, B.,Nagel, J.,Elling, R.A.,Liu, S.,Triantafellow, E.,Menon, S.,Wang, Z.,Honda, A.,Pardee, G.,Cantwell, J.,Luu, C.,Cornella-Taracido, I.,Harrington, E.,Fekkes, P.,Lei, H.,Fang, Q.,Digan, M.E.,Burdick, D.,Powers, A.F.,Helliwell, S.B.,D'Aquin, S.,Bastien, J.,Wang, H.,Wiederschain, D.,Kuerth, J.,Bergman, P.,Schwalb, D.,Thomas, J.,Ugwonali, S.,Harbinski, F.,Tallarico, J.,Wilson, C.J.,Myer, V.E.,Porter, J.A.,Bussiere, D.E.,Finan, P.M.,Labow, M.A.,Mao, X.,Hamann, L.G.,Manning, B.D.,Valdez, R.A.,Nicholson, T.,Schirle, M.,Knapp, M.S.,Keaney, E.P.,Murphy, L.O.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nat.Cell Biol., 16:1069-1079, 2014
Cited by
PubMed: 25327288
DOI: 10.1038/ncb3053
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

건을2024-03-27부터공개중

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