4PH4
The crystal structure of Human VPS34 in complex with PIK-III
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (B) | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 625 | 71845.0 | 1 | UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (Human) | PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34 |
2 | B (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
3 | C (B) | 4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diamine | non-polymer | 319.4 | 1 | Chemie (2UG) | |||
4 | D (B) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
B: 293 - 887 (UniProt: Q8NEB9)
PDB | External Database | Details |
---|---|---|
Met 263 | - | expression tag |
Ser 264 | - | expression tag |
Tyr 265 | - | expression tag |
Tyr 266 | - | expression tag |
His 267 | - | expression tag |
His 268 | - | expression tag |
His 269 | - | expression tag |
His 270 | - | expression tag |
His 271 | - | expression tag |
His 272 | - | expression tag |
Asp 273 | - | expression tag |
Tyr 274 | - | expression tag |
Asp 275 | - | expression tag |
Ile 276 | - | expression tag |
Pro 277 | - | expression tag |
Thr 278 | - | expression tag |
Thr 279 | - | expression tag |
Glu 280 | - | expression tag |
Asn 281 | - | expression tag |
Leu 282 | - | expression tag |
Tyr 283 | - | expression tag |
Phe 284 | - | expression tag |
Gln 285 | - | expression tag |
Gly 286 | - | expression tag |
Ala 287 | - | expression tag |
Met 288 | - | expression tag |
Gly 289 | - | expression tag |
Ser 290 | - | expression tag |
Gly 291 | - | expression tag |
Ile 292 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 71845.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 411.5 | |
All* | Total formula weight | 72256.5 |