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4PH4

The crystal structure of Human VPS34 in complex with PIK-III

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)
Phosphatidylinositol 3-kinase catalytic subunit type 3polymer62571845.01UniProt (Q8NEB9)
Pfam (PF00613)
Pfam (PF00454)
Homo sapiens (Human)PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34
2B
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
3C
(B)
4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diaminenon-polymer319.41Chemie (2UG)
4D
(B)
waterwater18.091Chemie (HOH)
Sequence modifications
B: 293 - 887 (UniProt: Q8NEB9)
PDBExternal DatabaseDetails
Met 263-expression tag
Ser 264-expression tag
Tyr 265-expression tag
Tyr 266-expression tag
His 267-expression tag
His 268-expression tag
His 269-expression tag
His 270-expression tag
His 271-expression tag
His 272-expression tag
Asp 273-expression tag
Tyr 274-expression tag
Asp 275-expression tag
Ile 276-expression tag
Pro 277-expression tag
Thr 278-expression tag
Thr 279-expression tag
Glu 280-expression tag
Asn 281-expression tag
Leu 282-expression tag
Tyr 283-expression tag
Phe 284-expression tag
Gln 285-expression tag
Gly 286-expression tag
Ala 287-expression tag
Met 288-expression tag
Gly 289-expression tag
Ser 290-expression tag
Gly 291-expression tag
Ile 292-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight71845.0
Non-Polymers*Number of molecules2
Total formula weight411.5
All*Total formula weight72256.5
*Water molecules are not included.

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PDB entries from 2024-11-06

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