4PGZ
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Summary for 4PGZ
Entry DOI | 10.2210/pdb4pgz/pdb |
Descriptor | Mast/stem cell growth factor receptor Kit, 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, kit receptor, igsf, cancer, surface receptor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 71050.96 |
Authors | Reshetnyak, A.V.,Boggon, T.J.,Lax, I.,Schlessinger, J. (deposition date: 2014-05-03, release date: 2015-03-18, Last modification date: 2023-12-27) |
Primary citation | Reshetnyak, A.V.,Opatowsky, Y.,Boggon, T.J.,Folta-Stogniew, E.,Tome, F.,Lax, I.,Schlessinger, J. The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. Mol.Cell, 57:191-201, 2015 Cited by PubMed: 25544564DOI: 10.1016/j.molcel.2014.11.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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