Summary for 4P7A
| Entry DOI | 10.2210/pdb4p7a/pdb |
| Descriptor | DNA mismatch repair protein Mlh1, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | structural genomics consortium, dna mismatch repair, dna damage, sgc, dna binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 39106.51 |
| Authors | Tempel, W.,Lam, R.,Zeng, H.,Walker, J.R.,Loppnau, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2014-03-26, release date: 2014-04-09, Last modification date: 2023-12-27) |
| Primary citation | Wu, H.,Zeng, H.,Lam, R.,Tempel, W.,Kerr, I.D.,Min, J. Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome. Acta Crystallogr.,Sect.F, 71:981-985, 2015 Cited by PubMed Abstract: Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson-Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot's syndromes. Although genetic testing for these mutations is available, robust classification of variants requires strong clinical and functional support. Here, the first structure of the N-terminus of human MLH1, determined by X-ray crystallography, is described. The structure shares a high degree of similarity with previously determined prokaryotic MLH1 homologs; however, this structure affords a more accurate platform for the classification of MLH1 variants. PubMed: 26249686DOI: 10.1107/S2053230X15010183 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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