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4P7A

Crystal Structure of human MLH1

Replaces:  3NA3
Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0006298biological_processmismatch repair
A0016887molecular_functionATP hydrolysis activity
A0030983molecular_functionmismatched DNA binding
A0032300cellular_componentmismatch repair complex
A0140664molecular_functionATP-dependent DNA damage sensor activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG A 401
ChainResidue
AASN38
AADP402
AHOH510
AHOH511
AHOH512

site_idAC2
Number of Residues23
Detailsbinding site for residue ADP A 402
ChainResidue
AILE68
AVAL76
ATHR81
ATHR82
ASER83
ALYS84
AARG100
AGLY101
AALA103
ALEU104
ATHR148
AMG401
AHOH503
AHOH510
AHOH511
AHOH512
AHOH513
AHOH517
AHOH520
AASN38
AALA42
AASP63
AGLY67

Functional Information from PROSITE/UniProt
site_idPS00058
Number of Residues7
DetailsDNA_MISMATCH_REPAIR_1 DNA mismatch repair proteins mutL / hexB / PMS1 signature. GFRGEAL
ChainResidueDetails
AGLY98-LEU104

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26249686","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4P7A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30770470","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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