Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain

Summary for 4P6W

DescriptorGlucocorticoid receptor, Nuclear receptor coactivator 2, MOMETASONE FUROATE, ... (4 entities in total)
Functional Keywordsmometasone furoate, glucocorticoid receptor, potency, hormone-hormone receptor complex, hormone receptor-hormone activator complex, hormone receptor/hormone activator
Biological sourceHomo sapiens (Human)
Cellular locationIsoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus  P04150
Nucleus Q15596
Total number of polymer chains2
Total molecular weight31212.09
He, Y.,Zhou, X.E.,Tolbert, W.D.,Powell, K.,Melcher, K.,Xu, H.E. (deposition date: 2014-03-25, release date: 2014-04-16, Last modification date: 2017-09-27)
Primary citation
He, Y.,Yi, W.,Suino-Powell, K.,Zhou, X.E.,Tolbert, W.D.,Tang, X.,Yang, J.,Yang, H.,Shi, J.,Hou, L.,Jiang, H.,Melcher, K.,Xu, H.E.
Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24:713-726, 2014
PubMed: 24763108 (PDB entries with the same primary citation)
DOI: 10.1038/cr.2014.52
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.224400.8%12.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution