4P6W
Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 252 | 29284.0 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 12 | 1406.6 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | MOMETASONE FUROATE | non-polymer | 521.4 | 1 | Chemie (MOF) PubChem (16757906) PubChem (4240) PubChem (176481392) PubChem (176481395) PubChem (176519923) PubChem (55188) PubChem (22852804) PubChem (441336) PubChem (26849679) PubChem (26849680) PubChem (22827688) PubChem (44287136) PubChem (25880677) PubChem (46782392) PubChem (56846412) PubChem (57077542) PubChem (51397103) PubChem (59936906) PubChem (57361952) PubChem (73265255) PubChem (73759807) PubChem (87411169) PubChem (88298293) PubChem (89292853) PubChem (6604444) PubChem (9874814) PubChem (88142733) PubChem (13888751) PubChem (9871375) PubChem (126963492) PubChem (12049723) PubChem (129010385) PubChem (129651457) PubChem (140417046) PubChem (143969929) PubChem (168322441) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 526 - 777 (UniProt: P04150)
B: 741 - 752 (UniProt: Q15596)
| PDB | External Database | Details |
|---|---|---|
| Ala 602 | Phe 602 | engineered mutation |
| Tyr 622 | Cys 622 | engineered mutation |
| Val 668 | Thr 668 | engineered mutation |
| Thr 674 | Ser 674 | engineered mutation |
| Ile 675 | Val 675 | engineered mutation |
| Ala 699 | Lys 699 | engineered mutation |
| Ala 703 | Lys 703 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 741 | Glu 741 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30690.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 521.4 | |
| All* | Total formula weight | 31212.1 |
