4P6W
Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 252 | 29284.0 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 12 | 1406.6 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | MOMETASONE FUROATE | non-polymer | 521.4 | 1 | Chemie (MOF) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 526 - 777 (UniProt: P04150)
B: 741 - 752 (UniProt: Q15596)
| PDB | External Database | Details |
|---|---|---|
| Ala 602 | Phe 602 | engineered mutation |
| Tyr 622 | Cys 622 | engineered mutation |
| Val 668 | Thr 668 | engineered mutation |
| Thr 674 | Ser 674 | engineered mutation |
| Ile 675 | Val 675 | engineered mutation |
| Ala 699 | Lys 699 | engineered mutation |
| Ala 703 | Lys 703 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 741 | Glu 741 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30690.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 521.4 | |
| All* | Total formula weight | 31212.1 |
