4P5M

Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergic Hypersensitivity and Autoimmunity

Summary for 4P5M

• Entry DOI: 10.2210/pdb4p5m/pdb
• Related: 4P4K 4P4R 4P57 4P5K
• Descriptor: HLA class II histocompatibility antigen, DP alpha 1 chain, peptide,HLA class II histocompatibility antigen, DP beta 1 chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: cbd, autoimmunity, beryllium, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P20036
• Total number of polymer chains: 8
• Total formula weight: 186417.68

Authors

Wang, Y.,Dai, S.,Kappler, J. (deposition date: 2014-03-18, release date: 2014-08-27, Last modification date: 2023-12-27)

• Primary citation: Clayton, G.M.,Wang, Y.,Crawford, F.,Novikov, A.,Wimberly, B.T.,Kieft, J.S.,Falta, M.T.,Bowerman, N.A.,Marrack, P.,Fontenot, A.P.,Dai, S.,Kappler, J.W.; Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.; Cell, 158:132-142, 2014; PubMed: 24995984; DOI: 10.1016/j.cell.2014.04.048

Experimental method

X-RAY DIFFRACTION (1.7 Å)