4P59
HER3 extracellular domain in complex with Fab fragment of MOR09825
Summary for 4P59
Entry DOI | 10.2210/pdb4p59/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-3, MOR09825 Fab fragment heavy chain, MOR09825 Fab fragment light chain, ... (6 entities in total) |
Functional Keywords | her3 receptor, therapeutic antibody, fab fragment, anti-her3, signaling protein, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 119419.80 |
Authors | Sprague, E.R. (deposition date: 2014-03-15, release date: 2014-04-16, Last modification date: 2023-09-27) |
Primary citation | Garner, A.P.,Bialucha, C.U.,Sprague, E.R.,Garrett, J.T.,Sheng, Q.,Li, S.,Sineshchekova, O.,Saxena, P.,Sutton, C.R.,Chen, D.,Chen, Y.,Wang, H.,Liang, J.,Das, R.,Mosher, R.,Gu, J.,Huang, A.,Haubst, N.,Zehetmeier, C.,Haberl, M.,Elis, W.,Kunz, C.,Heidt, A.B.,Herlihy, K.,Murtie, J.,Schuller, A.,Arteaga, C.L.,Sellers, W.R.,Ettenberg, S.A. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res., 73:6024-6035, 2013 Cited by PubMed: 23928993DOI: 10.1158/0008-5472.CAN-13-1198 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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