4P59
HER3 extracellular domain in complex with Fab fragment of MOR09825
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor tyrosine-protein kinase erbB-3 | polymer | 627 | 69164.4 | 1 | UniProt (P21860) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (Human) | Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3 |
| 2 | B (H) | MOR09825 Fab fragment heavy chain | polymer | 238 | 25480.2 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | MOR09825 Fab fragment light chain | polymer | 214 | 23262.8 | 1 | Homo sapiens | ||
| 4 | D, E (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | I, J (H, L) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 20 - 646 (UniProt: P21860)
| PDB | External Database | Details |
|---|---|---|
| Glu 641 | His 641 | cloning artifact |
| Phe 642 | Leu 642 | cloning artifact |
| Arg 643 | Thr 643 | cloning artifact |
| His 644 | Met 644 | cloning artifact |
| Asp 645 | Ala 645 | cloning artifact |
| Ser 646 | Leu 646 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117907.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 119419.8 |
