4P4R

Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergic Hypersensitivity and Autoimmunity

Summary for 4P4R

Entry DOI	10.2210/pdb4p4r/pdb
Related	4P4K 4P57 4P5K 4P5M
Descriptor	HLA class II histocompatibility antigen, DP alpha 1 chain, mim2 peptide,HLA class II histocompatibility antigen, DP beta 1 chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	hla-dp2, immune system, allergy, berylliosis
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P20036 P04440
Total number of polymer chains	4
Total formula weight	92012.27
Authors	Clayton, G.M.,Crawford, F.,Kappler, J.W. (deposition date: 2014-03-13, release date: 2014-07-16, Last modification date: 2023-12-27)
Primary citation	Clayton, G.M.,Wang, Y.,Crawford, F.,Novikov, A.,Wimberly, B.T.,Kieft, J.S.,Falta, M.T.,Bowerman, N.A.,Marrack, P.,Fontenot, A.P.,Dai, S.,Kappler, J.W. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell, 158:132-142, 2014 Cited by PubMed: 24995984 DOI: 10.1016/j.cell.2014.04.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation