4P4J

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor T33D

Summary for 4P4J

• Entry DOI: 10.2210/pdb4p4j/pdb
• Related: 4P4B 4P4D 4P4E 4P4F 4P4I
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609
• Total number of polymer chains: 1
• Total formula weight: 82924.90

Authors

Barinka, C. (deposition date: 2014-03-12, release date: 2015-05-20, Last modification date: 2020-07-29)

• Primary citation: Novakova, Z.,Cerny, J.,Choy, C.J.,Nedrow, J.R.,Choi, J.K.,Lubkowski, J.,Berkman, C.E.,Barinka, C.; Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities.; Febs J., 283:130-143, 2016; PubMed: 26460595; DOI: 10.1111/febs.13557

Experimental method

X-RAY DIFFRACTION (1.66 Å)