4P4D

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor MP1C

Summary for 4P4D

• Entry DOI: 10.2210/pdb4p4d/pdb
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, phosphoramidate, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 83246.22

Authors

Barinka, C. (deposition date: 2014-03-12, release date: 2015-05-20, Last modification date: 2020-07-29)

• Primary citation: Novakova, Z.,Cerny, J.,Choy, C.J.,Nedrow, J.R.,Choi, J.K.,Lubkowski, J.,Berkman, C.E.,Barinka, C.; Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities.; Febs J., 283:130-143, 2016; PubMed: 26460595; DOI: 10.1111/febs.13557

Experimental method

X-RAY DIFFRACTION (1.65 Å)