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4P2T

Crystal structure of Kaposi's sarcoma-associated herpesvirus (KSHV) protease in complex with a dimer disruptor

Summary for 4P2T
Entry DOI10.2210/pdb4p2t/pdb
DescriptorKSHV Protease, 6-(cyclohexylmethyl)-N-[4-(methylsulfonylcarbamoyl)-2-(phenylmethyl)phenyl]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordsprotein-protein interaction inhibition, serine protease, inhibitor complex, beta barrel and alpha helices, hydrolase
Biological sourceHuman herpesvirus 8 (HHV-8)
Total number of polymer chains2
Total formula weight44237.50
Authors
Gable, J.E. (deposition date: 2014-03-04, release date: 2014-07-16, Last modification date: 2023-09-27)
Primary citationGable, J.E.,Lee, G.M.,Jaishankar, P.,Hearn, B.R.,Waddling, C.A.,Renslo, A.R.,Craik, C.S.
Broad-spectrum allosteric inhibition of herpesvirus proteases.
Biochemistry, 53:4648-4660, 2014
Cited by
PubMed: 24977643
DOI: 10.1021/bi5003234
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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