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4P1R

Crystal Structure of PDE10A with Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors

Summary for 4P1R
Entry DOI10.2210/pdb4p1r/pdb
Related4P0N
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase-hydrolase inbhitor complex, hydrolase/hydrolase inbhitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q9Y233
Total number of polymer chains2
Total formula weight81937.94
Authors
Chmait, S. (deposition date: 2014-02-27, release date: 2014-07-23, Last modification date: 2023-12-27)
Primary citationHu, E.,Andrews, K.,Chmait, S.,Zhao, X.,Davis, C.,Miller, S.,Hill Della Puppa, G.,Dovlatyan, M.,Chen, H.,Lester-Zeiner, D.,Able, J.,Biorn, C.,Ma, J.,Shi, J.,Treanor, J.,Allen, J.R.
Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).
Acs Med.Chem.Lett., 5:700-705, 2014
Cited by
PubMed: 24944747
DOI: 10.1021/ml5000993
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.243 Å)
Structure validation

217705

數據於2024-03-27公開中

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