4P1R

Crystal Structure of PDE10A with Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors

4P1R の概要

• エントリーDOI: 10.2210/pdb4p1r/pdb
• 関連するPDBエントリー: 4P0N
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase-hydrolase inbhitor complex, hydrolase/hydrolase inbhitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q9Y233
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81937.94

構造登録者

Chmait, S. (登録日: 2014-02-27, 公開日: 2014-07-23, 最終更新日: 2023-12-27)

• 主引用文献: Hu, E.,Andrews, K.,Chmait, S.,Zhao, X.,Davis, C.,Miller, S.,Hill Della Puppa, G.,Dovlatyan, M.,Chen, H.,Lester-Zeiner, D.,Able, J.,Biorn, C.,Ma, J.,Shi, J.,Treanor, J.,Allen, J.R.; Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).; Acs Med.Chem.Lett., 5:700-705, 2014; PubMed: 24944747; DOI: 10.1021/ml5000993

実験手法

X-RAY DIFFRACTION (2.243 Å)