4P0V

Crystal structure of human farnesyl diphosphoate synthase in complex with zoledronate and taxodione

4P0V の概要

• エントリーDOI: 10.2210/pdb4p0v/pdb
• 分子名称: Farnesyl pyrophosphate synthase, ZOLEDRONIC ACID, (5beta)-11-hydroxyabieta-7,9(11),13-triene-6,12-dione, ... (5 entities in total)
• 機能のキーワード: human, fpps, inhibitor, complex, synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40575.01

構造登録者

Liu, Y.L.,Oldfield, E. (登録日: 2014-02-23, 公開日: 2014-07-02, 最終更新日: 2023-12-27)

• 主引用文献: Liu, Y.L.,Lindert, S.,Zhu, W.,Wang, K.,McCammon, J.A.,Oldfield, E.; Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.; Proc.Natl.Acad.Sci.USA, 111:E2530-E2539, 2014; PubMed: 24927548; DOI: 10.1073/pnas.1409061111

実験手法

X-RAY DIFFRACTION (2.4 Å)