4OYS

CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405.

4OYS の概要

• エントリーDOI: 10.2210/pdb4oys/pdb
• 分子名称: Phosphatidylinositol 3-kinase catalytic subunit type 3, SULFATE ION, (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one, ... (4 entities in total)
• 機能のキーワード: lipid kinase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69427.51

構造登録者

Mathieu, M.,Marquette, J.p. (登録日: 2014-02-13, 公開日: 2014-10-22, 最終更新日: 2024-03-27)

• 主引用文献: Ronan, B.,Flamand, O.,Vescovi, L.,Dureuil, C.,Durand, L.,Fassy, F.,Bachelot, M.F.,Lamberton, A.,Mathieu, M.,Bertrand, T.,Marquette, J.P.,El-Ahmad, Y.,Filoche-Romme, B.,Schio, L.,Garcia-Echeverria, C.,Goulaouic, H.,Pasquier, B.; A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.; Nat.Chem.Biol., 10:1013-1019, 2014; PubMed: 25326666; DOI: 10.1038/nchembio.1681

実験手法

X-RAY DIFFRACTION (2.9 Å)