4OV5

Structure of HLA-DR1 with a bound peptide with non-optimal alanine in the P1 pocket

Summary for 4OV5

• Entry DOI: 10.2210/pdb4ov5/pdb
• Related: 1AQD
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, HLA class I histocompatibility antigen, A-2 alpha chain, ... (4 entities in total)
• Functional Keywords: ig-like domain, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Membrane; Single-pass type I membrane protein: P01892
• Total number of polymer chains: 18
• Total formula weight: 269192.27

Authors

Trenh, P.,Yin, L.,Stern, L.J. (deposition date: 2014-02-20, release date: 2014-07-16, Last modification date: 2023-09-20)

• Primary citation: Yin, L.,Trenh, P.,Guce, A.,Wieczorek, M.,Lange, S.,Sticht, J.,Jiang, W.,Bylsma, M.,Mellins, E.D.,Freund, C.,Stern, L.J.; Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide.; J.Biol.Chem., 289:23449-23464, 2014; PubMed: 25002586; DOI: 10.1074/jbc.M114.585539

Experimental method

X-RAY DIFFRACTION (2.199 Å)