4ORY

Three-dimensional structure of the C65A-K59A double mutant of Human lipocalin-type Prostaglandin D Synthase holo, second crystal form

Summary for 4ORY

Entry DOI	10.2210/pdb4ory/pdb
Related	4ORR 4ORS 4ORU 4ORW 4ORX 4OS0 4OS3 4OS8
Descriptor	Prostaglandin-H2 D-isomerase, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL (3 entities in total)
Functional Keywords	lipocalin-type prostaglandin-d synthase, isomerase
Biological source	Homo sapiens (human)
Cellular location	Rough endoplasmic reticulum : P41222
Total number of polymer chains	8
Total formula weight	170119.83
Authors	Perduca, M.,Bovi, M.,Bertinelli, M.,Bertini, E.,Destefanis, L.,Carrizo, M.E.,Capaldi, S.,Monaco, H.L. (deposition date: 2014-02-12, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citation	Perduca, M.,Bovi, M.,Bertinelli, M.,Bertini, E.,Destefanis, L.,Carrizo, M.E.,Capaldi, S.,Monaco, H.L. High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase. Acta Crystallogr.,Sect.D, 70:2125-2138, 2014 Cited by PubMed: 25084332 DOI: 10.1107/S1399004714012462 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation