4ORY

Three-dimensional structure of the C65A-K59A double mutant of Human lipocalin-type Prostaglandin D Synthase holo, second crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036094	molecular_function	small molecule binding
B	0036094	molecular_function	small molecule binding
C	0036094	molecular_function	small molecule binding
D	0036094	molecular_function	small molecule binding
E	0036094	molecular_function	small molecule binding
F	0036094	molecular_function	small molecule binding
G	0036094	molecular_function	small molecule binding
H	0036094	molecular_function	small molecule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE PEU E 201

Chain	Residue
E	ASN51
E	MET145
F	SER45
F	LEU48
F	ASN51
F	SER52
F	LEU55
F	LEU79
F	ARG92
F	MET94
F	SER133
E	SER52
F	PRO139
F	PHE143
F	MET145
F	THR147
F	HOH208
E	LEU55
E	ARG92
E	MET94
E	TYR107
E	TRP112
E	SER133
E	PHE143

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site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE PEU G 201

Chain	Residue
G	SER45
G	ASN51
G	SER52
G	LEU55
G	ALA59
G	ARG92
G	MET94
G	TRP112
G	TYR116
G	VAL118
G	SER133
G	PHE143
G	MET145
G	THR147
G	HOH317
H	ASN51
H	SER52
H	LEU62
H	ARG92
H	SER133
H	ASP142
H	MET145
H	HOH215

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Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	14
Details	LIPOCALIN Lipocalin signature. NFQqdKFLGRWFSA

Chain	Residue	Details
A	ASN33-ALA46

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:20667974

Chain	Residue	Details
A	ALA65
B	ALA65
C	ALA65
D	ALA65
E	ALA65
F	ALA65
G	ALA65
H	ALA65

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:23234360

Chain	Residue	Details
A	SER29
B	SER29
C	SER29
D	SER29
E	SER29
F	SER29
G	SER29
H	SER29

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:8336134

Chain	Residue	Details
A	ASN51
B	ASN51
C	ASN51
D	ASN51
E	ASN51
F	ASN51
G	ASN51
H	ASN51

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site_id	SWS_FT_FI4
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:8336134

Chain	Residue	Details
A	ASN78
B	ASN78
C	ASN78
D	ASN78
E	ASN78
F	ASN78
G	ASN78
H	ASN78

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