4OQH
Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation in complex with boron-based inhibitor EC25
Summary for 4OQH
Entry DOI | 10.2210/pdb4oqh/pdb |
Related | 4IBR 4IBX 4OP5 4OP8 4OPQ 4OPR 4OPY 4OPZ 4OQ0 4OQG 4OQI |
Descriptor | Extended spectrum beta-lactamase TEM-63, 1,2-ETHANEDIOL, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 29144.96 |
Authors | Dellus-Gur, E.,Elias, M.,Fraser, J.S.,Tawfik, D.S. (deposition date: 2014-02-09, release date: 2015-05-20, Last modification date: 2018-01-17) |
Primary citation | Dellus-Gur, E.,Elias, M.,Caselli, E.,Prati, F.,Salverda, M.L.,de Visser, J.A.,Fraser, J.S.,Tawfik, D.S. Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder. J. Mol. Biol., 427:2396-2409, 2015 Cited by PubMed: 26004540DOI: 10.1016/j.jmb.2015.05.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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