4OQB
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide
Summary for 4OQB
Entry DOI | 10.2210/pdb4oqb/pdb |
Related | 4DQY 4OPX 4OQA |
Descriptor | Poly [ADP-ribose] polymerase 1, DNA (26-MER), ZINC ION, ... (5 entities in total) |
Functional Keywords | zinc finger, dna binding, parp, polymerase, dna repair, poly(adp-ribosyl)ation, transferase-dna-transferase inhibitor complex, transferase/dna/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P09874 P09874 |
Total number of polymer chains | 6 |
Total formula weight | 191746.46 |
Authors | Pascal, J.M.,Steffen, J.D. (deposition date: 2014-02-07, release date: 2014-07-02, Last modification date: 2023-09-20) |
Primary citation | Patel, M.R.,Bhatt, A.,Steffen, J.D.,Chergui, A.,Murai, J.,Pommier, Y.,Pascal, J.M.,Trombetta, L.D.,Fronczek, F.R.,Talele, T.T. Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J.Med.Chem., 57:5579-5601, 2014 Cited by PubMed: 24922587DOI: 10.1021/jm5002502 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.362 Å) |
Structure validation
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