4OON

Crystal structure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid)

Summary for 4OON

Entry DOI	10.2210/pdb4oon/pdb
Related	4OOL 4OOM
Descriptor	Penicillin-binding protein 1A, (4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid (3 entities in total)
Functional Keywords	pbp1a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Pseudomonas aeruginosa PAO1
Cellular location	Cell inner membrane; Single-pass type II membrane protein (By similarity): Q07806
Total number of polymer chains	1
Total formula weight	89044.30
Authors	Han, S.,Caspers, N.,Knafels, J.D. (deposition date: 2014-02-03, release date: 2014-05-07, Last modification date: 2024-03-06)
Primary citation	Starr, J.,Brown, M.F.,Aschenbrenner, L.,Caspers, N.,Che, Y.,Gerstenberger, B.S.,Huband, M.,Knafels, J.D.,Lemmon, M.M.,Li, C.,McCurdy, S.P.,McElroy, E.,Rauckhorst, M.R.,Tomaras, A.P.,Young, J.A.,Zaniewski, R.P.,Shanmugasundaram, V.,Han, S. Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. J.Med.Chem., 57:3845-3855, 2014 Cited by PubMed: 24694215 DOI: 10.1021/jm500219c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation