4OOL

Crystal structure of PBP3 in complex with compound 14 ((2E)-2-({[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methoxy]imino}acetyl]amino}-3-oxopropyl]oxy}imino)pentanedioic acid)

Summary for 4OOL

• Entry DOI: 10.2210/pdb4ool/pdb
• Related: 4OOM 4OON
• Descriptor: Cell division protein FtsI [Peptidoglycan synthetase], (2E)-2-({[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methoxy]imino}acetyl]amino}-3-oxopropyl]oxy}imino)pentanedioic acid (3 entities in total)
• Functional Keywords: pbp3, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Pseudomonas aeruginosa PA1R
• Total number of polymer chains: 1
• Total formula weight: 58869.91

Authors

Han, S.,Caspers, N.,Knafels, J.D. (deposition date: 2014-02-03, release date: 2014-05-07, Last modification date: 2023-09-20)

• Primary citation: Starr, J.,Brown, M.F.,Aschenbrenner, L.,Caspers, N.,Che, Y.,Gerstenberger, B.S.,Huband, M.,Knafels, J.D.,Lemmon, M.M.,Li, C.,McCurdy, S.P.,McElroy, E.,Rauckhorst, M.R.,Tomaras, A.P.,Young, J.A.,Zaniewski, R.P.,Shanmugasundaram, V.,Han, S.; Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.; J.Med.Chem., 57:3845-3855, 2014; PubMed: 24694215; DOI: 10.1021/jm500219c

Experimental method

X-RAY DIFFRACTION (2.3 Å)