4OON
Crystal structure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004180 | molecular_function | carboxypeptidase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006508 | biological_process | proteolysis |
A | 0008360 | biological_process | regulation of cell shape |
A | 0008658 | molecular_function | penicillin binding |
A | 0008955 | molecular_function | peptidoglycan glycosyltransferase activity |
A | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
A | 0009252 | biological_process | peptidoglycan biosynthetic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0046677 | biological_process | response to antibiotic |
A | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 2U4 A 901 |
Chain | Residue |
A | GLN458 |
A | THR699 |
A | ASN700 |
A | ASP701 |
A | TYR733 |
A | HOH1001 |
A | HOH1002 |
A | SER461 |
A | SER520 |
A | ASN522 |
A | LEU559 |
A | THR680 |
A | THR696 |
A | GLY697 |
A | THR698 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU86 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Acyl-ester intermediate; for transpeptidase activity => ECO:0000250|UniProtKB:P02919 |
Chain | Residue | Details |
A | SER461 | |