4OMD
X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba
Summary for 4OMD
Entry DOI | 10.2210/pdb4omd/pdb |
Related | 1P8J 4OMC |
Related PRD ID | PRD_001221 |
Descriptor | Furin, phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total) |
Functional Keywords | pro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958 |
Total number of polymer chains | 12 |
Total formula weight | 319732.33 |
Authors | Dahms, S.O.,Than, M.E. (deposition date: 2014-01-27, release date: 2014-04-09, Last modification date: 2014-05-28) |
Primary citation | Dahms, S.O.,Hardes, K.,Becker, G.L.,Steinmetzer, T.,Brandstetter, H.,Than, M.E. X-ray Structures of Human Furin in Complex with Competitive Inhibitors. Acs Chem.Biol., 9:1113-1118, 2014 Cited by PubMed: 24666235DOI: 10.1021/cb500087x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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