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4OMC

X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba

Summary for 4OMC
Entry DOI10.2210/pdb4omc/pdb
Related1P8J 4OMD
Related PRD IDPRD_001220
DescriptorFurin, meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
Functional Keywordspro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
Total number of polymer chains12
Total formula weight320711.11
Authors
Dahms, S.O.,Than, M.E. (deposition date: 2014-01-27, release date: 2014-04-09, Last modification date: 2014-05-28)
Primary citationDahms, S.O.,Hardes, K.,Becker, G.L.,Steinmetzer, T.,Brandstetter, H.,Than, M.E.
X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9:1113-1118, 2014
Cited by
PubMed: 24666235
DOI: 10.1021/cb500087x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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