4OMC

X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba

4OMC の概要

• エントリーDOI: 10.2210/pdb4omc/pdb
• 関連するPDBエントリー: 1P8J 4OMD
• 関連するBIRD辞書のPRD_ID: PRD_001220
• 分子名称: Furin, meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
• 機能のキーワード: pro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 320711.11

構造登録者

Dahms, S.O.,Than, M.E. (登録日: 2014-01-27, 公開日: 2014-04-09, 最終更新日: 2014-05-28)

• 主引用文献: Dahms, S.O.,Hardes, K.,Becker, G.L.,Steinmetzer, T.,Brandstetter, H.,Than, M.E.; X-ray Structures of Human Furin in Complex with Competitive Inhibitors.; Acs Chem.Biol., 9:1113-1118, 2014; PubMed: 24666235; DOI: 10.1021/cb500087x

実験手法

X-RAY DIFFRACTION (2.3 Å)