4OLH

Human GKRP Bound to AMG5106 and Sorbitol-6-Phosphate

Summary for 4OLH

• Entry DOI: 10.2210/pdb4olh/pdb
• Related: 4OHK 4OHM 4OHO 4OHP 4OP1 4OP2 4OP3
• Descriptor: Glucokinase Regulatory Protein, 2-(2-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}-3,3'-bipyridin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• Functional Keywords: sis domain, regulatory protein, binds to and inhibits glucokinase, glucokinase, liver, carbohydrate binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q14397
• Total number of polymer chains: 2
• Total formula weight: 146069.21

Authors

Jordan, S.R.,Chmait, S. (deposition date: 2014-01-23, release date: 2014-07-23, Last modification date: 2023-09-20)

• Primary citation: Hong, F.T.,Norman, M.H.,Ashton, K.S.,Bartberger, M.D.,Chen, J.,Chmait, S.,Cupples, R.,Fotsch, C.,Jordan, S.R.,Lloyd, D.J.,Sivits, G.,Tadesse, S.,Hale, C.,St Jean, D.J.; Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.; J.Med.Chem., 57:5949-5964, 2014; PubMed: 25001129; DOI: 10.1021/jm5001979

Experimental method

X-RAY DIFFRACTION (2.4 Å)