4OLH

Human GKRP Bound to AMG5106 and Sorbitol-6-Phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucokinase Regulatory Protein	polymer	638	70306.6	2	UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741)	Homo sapiens (human)	Glucokinase regulator
2	C, R (A, B)	2-(2-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}-3,3'-bipyridin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol	non-polymer		562.5	2	Chemie (2TO)
3	D, S (A, B)	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P)
4	AA, BA, CA, DA, E... (B, A)	IODIDE ION	non-polymer		126.9	27	Chemie (IOD)
5	HA (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	IA, JA, KA (B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	LA, MA (A, B)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -11	-	expression tag
Ala -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Gly 626	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140613.2
Non-Polymers*	Number of molecules	35
	Total formula weight	5456.0
All*	Total formula weight	146069.2

*Water molecules are not included.