4OJR

Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264

Summary for 4OJR

• Entry DOI: 10.2210/pdb4ojr/pdb
• Descriptor: HIV-1 Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, ... (5 entities in total)
• Functional Keywords: viral dna integration, dna binding, ledgf binding, viral protein
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• Total number of polymer chains: 1
• Total formula weight: 18763.05

Authors

Gupta, K.,Brady, T.,Dyer, B.,Hwang, Y.,Male, F.,Nolte, R.T.,Wang, L.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.,Bushman, F.D. (deposition date: 2014-01-21, release date: 2014-06-11, Last modification date: 2024-02-28)

• Primary citation: Gupta, K.,Brady, T.,Dyer, B.M.,Malani, N.,Hwang, Y.,Male, F.,Nolte, R.T.,Wang, L.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D.; Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS.; J.Biol.Chem., 289:20477-20488, 2014; PubMed: 24904063; DOI: 10.1074/jbc.M114.551119

Experimental method

X-RAY DIFFRACTION (1.82 Å)