4OJR

Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264

4OJR の概要

• エントリーDOI: 10.2210/pdb4ojr/pdb
• 分子名称: HIV-1 Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, ... (5 entities in total)
• 機能のキーワード: viral dna integration, dna binding, ledgf binding, viral protein
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18763.05

構造登録者

Gupta, K.,Brady, T.,Dyer, B.,Hwang, Y.,Male, F.,Nolte, R.T.,Wang, L.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.,Bushman, F.D. (登録日: 2014-01-21, 公開日: 2014-06-11, 最終更新日: 2024-02-28)

• 主引用文献: Gupta, K.,Brady, T.,Dyer, B.M.,Malani, N.,Hwang, Y.,Male, F.,Nolte, R.T.,Wang, L.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D.; Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS.; J.Biol.Chem., 289:20477-20488, 2014; PubMed: 24904063; DOI: 10.1074/jbc.M114.551119

実験手法

X-RAY DIFFRACTION (1.82 Å)