4OHD
LEOPARD Syndrome-Associated SHP2/A461T mutant
Summary for 4OHD
Entry DOI | 10.2210/pdb4ohd/pdb |
Related | 4OHE 4OHH 4OHI 4OHL 4OHT |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total) |
Functional Keywords | sh2 domain, phosphatase domain, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 61791.66 |
Authors | Yu, Z.H.,Zhang, R.Y.,Walls, C.D.,Chen, L.,Zhang, S.,Wu, L.,Wang, L.,Liu, S.,Zhang, Z.Y. (deposition date: 2014-01-17, release date: 2014-09-24, Last modification date: 2023-09-20) |
Primary citation | Yu, Z.H.,Zhang, R.Y.,Walls, C.D.,Chen, L.,Zhang, S.,Wu, L.,Liu, S.,Zhang, Z.Y. Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53:4136-4151, 2014 Cited by PubMed: 24935154DOI: 10.1021/bi5002695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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