4OHD
LEOPARD Syndrome-Associated SHP2/A461T mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 536 | 61791.7 | 1 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3 |
| 2 | B (A) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 1 - 528 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| - | Gln 408 | deletion |
| - | Ala 409 | deletion |
| - | Leu 410 | deletion |
| - | Leu 411 | deletion |
| Thr 461 | Ala 465 | engineered mutation |
| Leu 529 | - | expression tag |
| Glu 530 | - | expression tag |
| His 531 | - | expression tag |
| His 532 | - | expression tag |
| His 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61791.7 | |
| All* | Total formula weight | 61791.7 |
