4OGI
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536
Summary for 4OGI
Entry DOI | 10.2210/pdb4ogi/pdb |
Related | 4OGJ |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ... (4 entities in total) |
Functional Keywords | bromodomain, bromodomain containing protein 4, plk1 kinase inhibitor, structural genomics, structural genomics consortium, sgc, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 2 |
Total formula weight | 31366.20 |
Authors | Filippakopoulos, P.,Picaud, S.,Jose, B.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-01-16, release date: 2014-02-26, Last modification date: 2023-09-20) |
Primary citation | Ciceri, P.,Muller, S.,O'Mahony, A.,Fedorov, O.,Filippakopoulos, P.,Hunt, J.P.,Lasater, E.A.,Pallares, G.,Picaud, S.,Wells, C.,Martin, S.,Wodicka, L.M.,Shah, N.P.,Treiber, D.K.,Knapp, S. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat.Chem.Biol., 10:305-312, 2014 Cited by PubMed: 24584101DOI: 10.1038/nchembio.1471 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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