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4OGI

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE R78 A 202
ChainResidue
ALEU94
AASN140
AHOH301
AHOH358
AHOH359
AHOH380
AHOH412
BR78202
ATRP81
APRO82
AVAL87
ALEU92

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 201
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE R78 B 202
ChainResidue
AR78202
BTRP81
BPRO82
BVAL87
BLEU92
BLEU94
BASN140
BILE146
BHOH301
BHOH306
BHOH313
BHOH376

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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