4OGJ

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348

Summary for 4OGJ

Entry DOI	10.2210/pdb4ogj/pdb
Related	4OGI
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, ... (4 entities in total)
Functional Keywords	bromodomain, bromodomain containing protein 4, jak2 kinase inhibitor, flt3 kinase inhibitor, structural genomics, structural genomics consortium, sgc, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	31434.32
Authors	Filippakopoulos, P.,Picaud, S.,Jose, B.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-01-16, release date: 2014-02-26, Last modification date: 2023-09-20)
Primary citation	Ciceri, P.,Muller, S.,O'Mahony, A.,Fedorov, O.,Filippakopoulos, P.,Hunt, J.P.,Lasater, E.A.,Pallares, G.,Picaud, S.,Wells, C.,Martin, S.,Wodicka, L.M.,Shah, N.P.,Treiber, D.K.,Knapp, S. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat.Chem.Biol., 10:305-312, 2014 Cited by PubMed: 24584101 DOI: 10.1038/nchembio.1471 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation