4OF5
Refinement of RAGE-DNA complex in 3S59 without DNA
Summary for 4OF5
| Entry DOI | 10.2210/pdb4of5/pdb |
| Descriptor | Advanced glycosylation end product-specific receptor (1 entity in total) |
| Functional Keywords | membrane, signaling proteinig domain, receptor, s100 proteins ab oligomer age dna, signaling protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 10: Cell membrane ; Single-pass type I membrane protein : Q15109 |
| Total number of polymer chains | 2 |
| Total formula weight | 48391.16 |
| Authors | Yatime, L.,Andersen, G.R. (deposition date: 2014-01-14, release date: 2014-04-23, Last modification date: 2025-03-12) |
| Primary citation | Yatime, L.,Andersen, G.R. The specificity of DNA recognition by the RAGE receptor. J.Exp.Med., 211:749-750, 2014 Cited by PubMed Abstract: A recent paper by Sirois et al. in The Journal of Experimental Medicine reports that the receptor for advanced glycation end-products (RAGE) promotes uptake of DNA into endosomes and lowers the immune recognition threshold for the activation of Toll-like receptor 9. Two crystal structures suggested that the DNA phosphate-deoxyribose backbone is recognized by RAGE through well-defined interactions. However, the electron densities for the DNA molecules are weak enough that the presented modeling of DNA is questionable, and models only containing RAGE account for the observed diffraction data just as well as the RAGE-DNA complexes presented by the authors. PubMed: 24778420DOI: 10.1084/jem.20132526 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.803 Å) |
Structure validation
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