4OCC

co-crystal structure of MDM2(17-111) in complex with compound 48

Summary for 4OCC

Entry DOI	10.2210/pdb4occ/pdb
Related	4ERE 4ERF 4OAS
Descriptor	E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (3 entities in total)
Functional Keywords	mdm2, p53, protein-protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	3
Total formula weight	35137.65
Authors	Huang, X. (deposition date: 2014-01-08, release date: 2014-04-02, Last modification date: 2024-02-28)
Primary citation	Gonzalez, A.Z.,Li, Z.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Duquette, J.,Eksterowicz, J.,Fox, B.M.,Fu, J.,Huang, X.,Houze, J.,Jin, L.,Li, Y.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Sun, D.,Medina, J.C. Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57:2963-2988, 2014 Cited by PubMed: 24601644 DOI: 10.1021/jm401911v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation