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4OCC

co-crystal structure of MDM2(17-111) in complex with compound 48

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
C0005634cellular_componentnucleus
C0043066biological_processnegative regulation of apoptotic process
C0051726biological_processregulation of cell cycle
E0005634cellular_componentnucleus
E0043066biological_processnegative regulation of apoptotic process
E0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 2TZ A 201
ChainResidue
ALEU54
AHOH383
EGLN18
EARG97
EHOH319
AGLY58
AGLN59
AILE61
AVAL93
ALYS94
AHIS96
AILE99
ATYR100

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 2TZ C 201
ChainResidue
AHOH345
CLEU54
CGLY58
CGLN59
CILE61
CVAL93
CLYS94
CHIS96
CILE99
CTYR100
CHOH332
CHOH397

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 2TZ E 201
ChainResidue
CARG97
ELEU54
EVAL93
ELYS94
EHIS96
ETYR100
EHOH343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues249
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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